Influence of doxorubicin on the extracellular matrix of the liver of rats under conditions of chronic alcoholic hepatitis

The liver has a high regenerative potential that is dependent on many factors, in particular adenosine monophosphate kinase signaling, however, long-term alteration, such as daily alcohol consumption, turns regeneration into chronic disease fibrosis, the end stage of which cirrhosis. Hepatic extracellular matrix proteins are important triggers enhanced stellate cell function during progression fibrosis. experiments were performed Wistar rats divided four groups: control group; doxorubicin injection group (1.25 mg/kg); hepatitis alcoholic group, where we studied total concentration glycosaminoglycans, heparin-heparan, keratan-dermatan and chondroitin fractions free oxyproline sialic acids tissue homogenate. Cells with Mallory-Denk bodies present from consisted tangled balls intermediate filaments showed eosinophilia cytoplasm degenerative hepatocytes. There also necrotic changes cells. Sinusoidal capillaries locally dilated. In central sections lobules injected against background hepatitis, veins expanded, their endothelium was thinned. there no blood cells lumens. nuclei vast majority hepatocytes state karyopyknosis, karyorrhexis, karyolysis. Administration to animals leads an increase sulfates, decrease heparin-heparan fraction glycosaminoglycans compared group. concentrations fraction, significantly increased, content decreased hepatitis. by 1.25 times, – 1.36 ethanol or combination causes morphological characteristic lobules. administration prevents alcohol-induced collagenolysis breakdown glycoproteins, but increases proteoglycans due fractions.